He currently provides interior art and covers for IDW's Teenage Mutant Ninja Turtles.
Among past notable projects are Dial H for DC Comics' New 52 and written by China Miéville, 2 Guns for BOOM! Studios which recently became a major motion picture starring Mark Wahlberg and Denzel Washington, he was also a co-creator on that book. He drew the third issue of Ales Kot's ZERO for Image Comics.
Santolouco resides in Porto Alegre, Southern Brazil.