Mary Jane appears in 3148 issues.
On Earth-91110, Captain Universe had come to believe that Mary Jane's needs were distracting Spider-Man from his duties and therefore were interfering with the needs of the many. In response to this Captain Universe used his influence over Peter to drive him and Mary Jane apart, nearly destroying their marriage in the process.
An egotistical con-artist and corporate thief who used his ill-gotten resources to develop his own version of Doctor Octopus's mechanical arms.
Carnage is the result of a spawning of a separate extraterrestrial symbiote worn by Venom. Carnage bonded with serial killer Cletus Kasady, creating one of Spider-Man’s most murderous adversaries.
Mary Jane once defeated the Chameleon by knocking him out with a baseball bat. This would later be referred to as an embarrassing moment for the Chameleon.
Gregori kidnapped Mary Jane.
Eddie Brock bonded to the alien symbiote after it was discarded by Spider-Man, becoming the first Venom. Brock was later Anti-Venom, but the symbiote was lost during Spider-Island. Brock has also been forcibly bonded to the Toxin symbiote by the Crime Master, but has reluctantly given it up to stop Carnage. He has recently been rebonded with Venom.
Model Elyse Nelson was named the Slasher in newspaper when she started killing other models.
He and Mary Jane confronted in Spectacular Spider-man series
Member of the Repo Squad. Wears a variation of the Beetle armor.
Hijack (David Bond) is a new mutant that appeared in Atlanta. He has the power to control machines, and was recruited by Magik and the Stepford Cuckoos, who saved him from two armed police men.
The Hypno-Hustler is a jive-talking black soul Disco singer who uses his goggles and evil boots of death to hypnotize music lovers, alongside his backup band, "The Mercy Killers."
The abusive ex boyfriend of Dia Sloane.
Jerome was an actor who worked with Mary Jane Watson-Parker and failingly tried to seduce her. However, his history and future are far more interesting than this one little stint as he is actually the creation of an Illuminati experiment and has access to great powers beyond the reality divide.
Billy "The Beaut" Russo was known for his handsome appearance until confronting the Punisher who sent Billy through a glass window, severely damaging his face. After the incident he took the name Jigsaw and is a deadly force with a vendetta towards the Punisher.
Member of the Repo Squad. Wore a variation of the Beetle suit.
A former mad, obsessive stalker of Mary Jane Watson.
The self-proclaimed kingpin of crime, Wilson Fisk is one of the most prominent figures of organized crime in the United States.
He is the king of mobsters, controlling organized crime on the East Coast with an iron fist.
MJ is the wife of Peter Parker (Spider-Man). She is the 4th love interest in Parker's life behind Liz Allan, Betty Brant, and Gwen Stacy. She is also a professional model and actress.
Maggie Lorca is a reporter for the Daily Bugle.
Mephisto annulled Peter and Mary Jane's marriage.
An almost lookalike Mary Jane Watson, Miranda was a beautiful film actress, but a tragic incident left her injured for the rest of her life.
Normie Osborn's secretary.
Daniel Berkhart was the second person to call themselves Mysterio and cellmate to the original Mysterio. After the supervillain's suicide, Berkhart took up the mantle of Mysterio.
A former photographer of Daily Bugle and one of the biggest sleaze-bags you could ever hope to meet.
After he was horribly disfigured he soon took his anger out on the world.
Servant of Lord Tantalus.
One of Spider-Man's new Brand New Day villains, she has the power to flatten herself to the size of paper, as well as those she attacks. She is also has chameleon-like abilities, able to blend into any sort of scenery. She is obsessed with actor Bobby Carr.
Son of the creator of the Living Brain and enemy of Spider-Man.
After his family was killed by the mob, U.S. Marine Special Forces veteran Frank Castle vowed to avenge their deaths and became a one-man army in his personal war against the criminal underworld. With a distinct death's head skull adorning his chest, Frank Castle became the vigilante known as the Punisher.
The omnipotent ruler of the Regency who slaughtered all of its superheroes and harvested their powers years ago.
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