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Once a small-time crook, Parker Robbins found a mystical cloak and pair of boots that endowed him with supernatural abilities, allowing for his rise to power as a skilled sorcerer and feared crime lord.
Piranha is a fish that was mutated into humanoid form.
Black Talon derives his power from the mystic Voodoo arts. He can raise zombies and control them at will.
Justine Hammer, aka "The Crimson Cowl", was the leader of the Masters of Evil and battled the Thunderbolts. The daughter of Justin Hammer and mother to Sasha Hammer she has recently followed in her fathers footsteps and took control of Hammer industries. She was ultimately killed by Zeke Stane.
A former CIA Agent who became a criminal and organized an army of mercenaries, Crossfire lost his left eye and left ear in an explosion, replacing them with cybernetic implants. He primarily antagonizes Hawkeye, and by extension Mockingbird and the Avengers. However, he ultimately goes where the money is.
Dansen Macabre is a member of the Night Shift with mystical dancing abilities. Her dance can hypnotize and even kill those who watch it.
Needle is an older tailor who was mugged and lost one of his eyes. But he also gained a power to paralyze people with his gaze of his good eye.
Digger is a villain who buries people alive. Also somewhat of a storyteller.
Deadpool from Earth-2149 who ended up in Earth-616. Currently only a head, and a member of Deadpool Corps.
Denying his infernal heritage, the Son of Satan uses his abilities for the betterment of mankind, but has at times succumbed to his darker, demonic side, even clashing brutally with the forces of both Heaven and Hell.
A genius in numerous fields, Centurius discovered ways to evolve living things at an accelerated rate. Using these methods on himself, he is now virtually ageless and seeks to remake the world as he sees fit.
Joaquin Pennysworth is the current Nighthawk and leads his own team of Defenders independent from the main team. A former SHIELD agent, Pennysworth took up the Nighthawk mantle when Kyle Richmond was forced to retire.
Captain Mexica is an alternate version of Captain America from a reality where the Aztec Empire never fell.
Razor Wire was a member of the Wicked Brigade, a group of Spider-Man villains.
Lightning Fist was a member of the Wicked Brigade, a group of Spider-Man villains.
Ogre is a member of the Wicked Brigade, a group of Spider-Man villains.
The Revenant was an airborne virus which was unleashed on the island nation of Taino.
Dormammu is the older twin brother of Umar and Ruler of the Dark Dimension, a being of immense mystical power. He uses his vast powers to conquer other universes and dimensions, earning himself the enmity of Doctor Strange in the process.
Tatterdemalion is a tap dancer and actor, turned criminal.
Killed by his gardener Gyps and brought back from the dead by means of Voodoo, Simon William Garth unwillingly became the Zombie.
Warlord Krang is a nobleman of Atlantis and a long time foe of Prince Namor the Sub-Mariner.
John Kelly was the first attempt at creating a Deathlok cyborg. However, when the project failed he was killed. His brain patterns were later discovered by Michael Collins, as Deathlok, and reluctantly digitized into another cyborg body. John Kelly became the cyborg known as Siege.
Director of A.R.M.O.R., Charles Little Sky is a mutant with the power to create portals to other dimensions.
A young woman whom encountered the Man-Thing. She became a powerful and skilled sorceress with extensive knowledge of magic and arcane lore. She is also the cousin of Johnny Blaze and Dan Ketch.
Wade Wilson is a former test subject of the Weapon X program, where he received his regenerative healing factor through the scientific experiments conducted upon him. A prominent enemy, ally and later, member of X-Force. He's famous for breaking the Fourth Wall.
Mutant Mandrill super-villain. His true power lied in the incredible ability to control females with his pheromones.
Once Michael Morbius was a world-renowned bio-chemist, dying of an unknown blood disease and desperately searching for a cure. He found that cure, but, in turn, it afflicted him with a curse far worse than any possible disease; the curse of the blood-sucking night-beast; the curse of the Living Vampire.
Man-Thing is a powerful swamp creature and guardian of the Nexus of all Realities. He was once human and turned himself into a monster as a last act of defense and a way too avoid his serum falling in the wrong hands.
Victim of an ancient family curse, Jack Russell struggled for years with his bestial alter-ego. But over time has conquered his inner demons. Now he fights the dark forces that plague our world. He is an enforcer of justice, an avenger of shadows, and a Werewolf By Night.
Kyle Richmond was a thrill-seeking playboy who became the costumed adventurer Nighthawk. Starting out as a villain, Richmond soon found altruism a greater pursuit. As Nighthawk, he became mainstay of the Defenders, and has also acted alongside the Squadron Supreme, the Redeemers, the Thunderbolts and the Initiative.
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