Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, which he could have prevented, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became the Amazing Spider-Man!
A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong. From that day forward, he has set out to prove his superior intellect in a number of ways, but these plans are usually thwarted by Spider-Man.
The Venom symbiote bonded with Spider-Man during his adventure in the first "Secret Wars" on the Beyonder's makeshift planet called Battleworld. Initially, he thought the symbiote was just a costume. However upon his discovery that it was sentient, he rejected it. Since then, the symbiote has bonded with several different hosts, the most well-known being Eddie Brock and Flash Thompson.
Flash attended the same high school and university as Peter Parker, who would later be known as Spider-Man. He frequently bullied Peter but was actually Spider-Man's greatest fan. In time Flash befriended Peter, becoming a decorated war hero and was bonded to the Venom symbiote. Some time after losing the symbiote, Flash became the new Anti-Venom.
Patrick was cloned from the body of Michael Van Patrick (MVP) of the Initiative after his death, and is one of the Initiative's Scarlet Spiders. He is the last surviving Scarlet Spider.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
Originally created in the Ultimate Universe, this version of Spider-Man is a 16 year old kid named Miles Morales from Brooklyn who takes on the Spider-Man identity after Peter Parker's death. Miles discovers spider powers of his own after he was bitten by a spider 11 months before Peter's death, and uses these powers to be the best superhero he can be. Currently, Miles lives in the main Marvel Universe and is a member of the Champions.
A famous big game hunter, who became a mercenary and later, developed an intense obsession with restoring honor to his name. Kraven has been known as a major threat for Spider-Man and leaving a legacy during his demise.
During an experiment Dr. Curtis Connors accidentally turned into a ferocious reptilian monster who seeks to turn humans into lizards like himself. The Lizard is one of Spider-Man’s oldest and deadliest foes while ironically, his alter ego is a close friend and former teacher of Spidey’s alter ego Peter Parker.
Swindled by his business partner out of his equal share of the profits from their company, Adrian Toomes set out for revenge by using a flying harness of his own design. He has however, met defeat several times at the hands of his arch-nemesis, The Amazing Spider-Man.
Kaine was the first clone of Spider-Man created by the Jackal. He was suffering from clone degeneration and was used as a test subject until he fled. He became an assassin and spent years tormenting his clone brother Ben Reilly until he was eventually cured of his cellular degeneration and has taken up the mantle his now dead brother as the new Scarlet Spider.
Scientist Arnim Zola became one of the first biochemists in history after finding notes and equipment belonging to the offshoot race of humanity, the Deviants. He learned many things from his studies, including the ability to transfer people's essence into clones of their original bodies.
Luke Cage, wrongly convicted and unjustly imprisoned, was altered in a failed prison experiment that granted him unbreakable skin and superhuman strength. With his street smarts, and unending determination to do right, he fights for the common man! He eventually married Jessica Jones and had a daughter with her. Luke was also a member of The Avengers and the Leader of Thunderbolts for a time.
Dr. Stephen Strange was once a gifted but egotistical surgeon who sought out the Ancient One to heal his hands after they were wounded in a car accident. Instead, the Ancient One trained him to become Master of the Mystic Arts and the Sorcerer Supreme of Earth.
Tyrone Johnson is the "dark" half of the vigilante duo known as Cloak and Dagger. After a drug-related experiment awakened his powers, he became a living personification of darkness. Cloak is the Yin to his partner Dagger's Yang. Superheroes of the streets, Cloak and Dagger wage a war against dangerous drugs and drug-related crimes.
The latest in a long line of warriors who wielded the power, Danny Rand is the immortal Iron Fist: protector of the mystical city of K'un Lun. He channels the soul of the dragon Shou-Lao making his fists into powerful weapons. He is among the best, if not the best fighter in the Marvel Universe. He has also been a member of The Defenders and the New Avengers.
Mercenary, formerly of the French Foreign Legion. He is one of the most formidable unarmed combatants in the world. He has mastered numerous martial arts and is perhaps the world's leading master of Savate, the French art of kick boxing. He is an accomplished thief and smuggler.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Tandy Bowen is the "light" half of the vigilante duo known as Cloak & Dagger. After a drug-related experiment awakened her powers, she became a living personification of light, with the ability to generate super-luminosity at will and use it both offensively and defensively.
Brawn over brains. The Rhino is an adversary of the amazing Spider-Man and incredible Hulk. His suit grants him immense endurance and strength. He recently returned to a life of crime following an all too brief retirement.
Baron Mordo is an accomplished user of magic who was trained by the Ancient One. He was a long time foe of Dr. Strange.
Harry Osborn is the best friend of Peter Parker, the Amazing Spider-Man. His father is Norman Osborn, a global industrialist and billionaire.
Nicholas Joseph Fury served in World War II as the leader of the Howling Commandos. He later became an agent, and eventually director, of S.H.I.E.L.D. Fury is one of the greatest strategic minds in the world, a born leader and a master of espionage. He currently serves as a replacement Watcher.
Former enemy of Spider-Man and the Fantastic Four, Sandman reformed after realising he was unhappy with his life. He joined the Avengers and later Silver Sable's Wild Pack. Sandman eventually returned to crime after being brainwashed by the Wizard, but sometimes still displays desire to better himself.
MacDonald Gargan was a failing private investigator that was turned into the Scorpion with financial help from J.Jonah Jameson. He became the host of the Venom symbiote and was part of Norman Osborn's Dark Avengers. After it was taken by the US Government and he became The Scorpion once again.
Former pro baseball player who became a known criminal as the Boomerang. After fighting towards some semblance of redemption as a member of the Thunderbolts, he lead the seventh incarnation of the Sinister Six.
The eighth smartest person on the planet, Amadeus Cho has a hypermind which allows him to run a virtually limitless amount of calculations in his head. Recently, he shouldered Banner's burden of being the Hulk. He absorbed some of the excess gamma radiation and cured Banner of his monster while granting himself the power he always wanted. After a climactic fight in the heart of Manhattan where he reconciled his personalities, he's now a slimmed down Hulk with a new superhero identity, Brawn.
Mister Negative's newest henchman, this is a second more powerful Rhino who wield a high-tech battle axe.
Ava Ayala is the younger sister of Hector Ayala (original White Tiger) and the aunt of the former White Tiger, Angela Del Toro. She is an Avengers Academy graduate, and the current wielder of the mystical Jade Tiger Amulet.
Jemma Simmons is a level 5 S.H.I.E.L.D. scientist. She is one of the youngest and most prominent members of S.H.I.E.L.D.'s research division, along with her inseparable friend Leo Fitz. She, along with Fitz, were recruited to Coulson's Team by Melinda May. While on the team, Simmons became friends with teammates Skye and Grant Ward.
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