Andi was one of the first neighbours Flash Thompson met in Philadelphia, who moved to live upstairs. Andi happened to attend West Philadelphia High School, where Flash started working as assistant coach. She usually skips gym, and one day she the only witness when Flash used his symbiotic-enhanced arm throw a ball to a bully, and came to the conclusion Thompson was Venom.
When mob boss Lord Ogre put a price to Venom's head, Andi was targeted by Jack O'Lantern, a villain who knew Flash's alter-ego. Venom couldn't save Andi's father from being stabbed by the maniac, but when Jack released a poisonous gas, Flash protected Andi with a portion of his symbiote, which ended up bonding with Andrea rather than only protecting her from her death.