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Madame Cat is the daughter of Alexander Luthor, The Green Skull - leader of HYDRA. With the recruited help of Nuke, Baron Zero and Deathlok she succeeded in seemingly killing her father and becoming Hydra Supreme.

It is unknown if she survived the explosion of the Terra Cannon at HYDRA Headquarters when Bruce Wayne and SHIELD intervened. It seems this was all a plot by the still living Green Skull.

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