Perry was born in Mansfield, Ohio and raised in Fredericktown, Ohio, where he was the school mascot, the Fredericktown High School Freddie. His mother, Ann Bennett, was a homemaker, and his father, Coy Luther Perry, Jr., a steelworker. Luke Perry has revealed he likes to go home annually for the Fredericktown Tomato Show, an annual street fair.
Perry stated on The B.S. Report Podcast that he moved to Los Angeles shortly after high school to pursue acting as he didn't have any opportunities to do so in Ohio. He worked as a paver and lived in various cities including Huntington Beach, Long Beach, Downey, and Paramount.
As of March 4th 2019, Luke Perry passed away from from complications of a stroke.