Lois Lane appears in 5412 issues.
The original Atomic Skull, a scientist whose dedication to becoming immortal lead to the development of radioactive energy blasts and a turn towards supervillainy.
Originally a hero who helped confront the Anti-Monitor during the Crisis on Infinite Earths, he returned, embittered by the failures of New Earth's heroes, intent on restoring the Multiverse at any cost.
The Anti-Monitor is the Monitor's counterpart from the Anti-matter Universe. He is responsible for the original Crisis on Infinite Earths, was the sole Guardian of the Sinestro Corps and once, against his will, was the source of the Black Lantern Corps Central Power Battery.
A one shot character who appeared in a Superman story in the pre-Crisis universe.
The Batman Who Laughs is the Dark Knight of Earth -22, and the chosen herald of Barbatos. He was infected by a nanotoxin in the Joker's bloodstream upon his enemy's death, and the combination of the Joker's depravity and Bruce Wayne's tactical mind created the deadliest villain his planet had ever seen.
Bizarro is an imperfect duplicate of Superman. Everything Bizarro does is deliberately backwards or the opposite of normal.
Brainiac is one of Superman's oldest and most powerful foes. A techno-organic being with a twelfth-level intellect and hyper-advanced technology, he travels the multiverse seeking civilizations to shrink and abduct, which he then adds to his collection of captured worlds. He has been responsible for the extinction of countless cultures and the deaths of untold billions.
Devoted follower of the Crime Bible and leader of Intergang. He's one of the most powerful gangsters in Metropolis and a psychopath, who worships the idea of crime itself.
Earth-2 Bizarro, he briefly supplanted Earth-2 Superman, Kal-L.
Butch Matson is the infamous panicked mug on the cover of Action Comics #1 and, arguably, the first nameable villain in any of the Superman titles. He comes into conflict with Superman when he kidnaps Lois Lane from her cab after she spurns his advances at a roadhouse.
Clawster kidnapped Lois Lane.
He was a powerful Silver Age enemy of both Batman and Superman with the powers of all Legion of Super-Heroes members.
Former CIA experiment and operative with a super-powered suit of armor, and former childhood friend of Clark Kent.
With his organic parts genetically identical to Superman's, many believed that the former astronaut Hank Henshaw truly was the Last Son of Krypton restored to life after his death at the hands of Doomsday. Until he destroyed Coast City in Superman's name which led Hal Jordan to becoming a villain known as Parallax. Since then he has become a permanent menace for Superman and Green Lantern.
Cythonna killed a woman, whom was getting close to Clark earlier the day she arrived. She would have killed Lois if Superman had not intervened.
Uxas, famously known as Darkseid, is the supreme monarch of the ecumenopolis, Apokolips. Widely regarded as one of the Justice League's worst adversaries, the greatest enemy of New Genesis and one of the biggest threats to the DC Multiverse, he seeks to bend everything to his will and remake the cosmos in his image, while searching for the Anti-Life Equation, an equation which seemingly consists of immense power that has the potential to dominate all life in the DC Multiverse.
Genetically engineered to surpass all human limits, Slade Wilson was once a soldier but now works as one of the most feared assassins in the DC Universe. He has frequently clashed with the Teen Titans, Batman, Green Arrow, the Justice League, and even gods!
Came from an alternate dimension to kill Lois Lane. He was stopped by Superman.
Right-wing columnist for the Daily Planet who often came into conflict with Clark Kent and Perry White due to their differing political standings.
Doomsday is a seemingly unstoppable behemoth who adapts his physical form to overcome and destroy anything or anyone in his path. He is best known for being the murderer of Superman in the "Death of Superman" storyline.
Lois Lane is a prize winning reporter for the Daily Planet and Superman's wife. It was Lois who first foiled Wolfingham's plans. Buying stocks in one of his companies brought Lois- and soon after- Superman into close contact with Wilbur.
The Eradicator was built as a weapon by Superman's ancestor Kem-L. Its purpose was to alter the genes of Kryptonians and bind them to their planet. It built Superman's first Fortress of Solitude.
In Greek mythology, Eris is the Goddess of Chaos and Discord. She usually exerts her powers by means of a Golden Apple.
Evil Star relies upon the "star band" he created for both power and life.
General Dru-Zod was a member of the Kryptonian military, exiled to the Phantom Zone by Jor-El after attempting to conquer Krypton. When he escaped years later he targeted Superman and his adopted planet Earth.
Hecate or Hekate is a goddess in ancient Greek religion and mythology, most often shown holding a pair of torches or a key and in later periods depicted in triple form.
Leader of HORDR and copy of a Son of Vandal Savage who used his intellect and ability to transfer his consciousness into multiple nodes to prove himself to his father
Seemingly an ally at first, Illena of Kromal proved to be more than Superman bargained for.
Joker tried to kill Lois Lane in the Injustice: Gods Among Us.
William Rudolph's grandson, he is the creator and leader of The Ascension.
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