From a nursery rhyme where she sits on her tuffet eating her curds and whey until a spider comes along to to scare her away.
Grimm Fairy Tales
In Grimm Fairy Tales, Sela lives through a version of Little Miss Muffet's nursery rhyme when she is forced to confront her own actions. The analogy is somewhat different as Sela ends up trapped in a giant spider's web.
She apparently married to the spider and calling herself Mrs. Web, she is Fabletown's biggest gossip. She could also be seen as somewhat judgmental of people such as Snow White when she got pregnant by Bigby Wolf. She and her husband Mr. Web run Web 'n' Muffet's Market together. Her husband, the Spider, was one of the victims of Snow's son Ghost. She was later seen at Snow White's wedding, trying to catch the bouquet.