Lindsay McCabe is a close friend of Jessica Drew. She is an actress, having starred in a number of B-movies and a short-lived television series prior to meeting Jessica. She joined the Hatros Clinic, a "center for emotional studies", in attempt to improve her emotional stability and her acting skills. There she met Jessica who was trying to cope with her isolation from mainstream humanity. Drew's pheromones made women she met act instinctively hostile to her. Lindsay was the first not affected this way and the two soon became best friends and then roommates. They left the Clinic behind them.
Lindsay pursued further acting studies while Jessica a career as a private detective. Lindsay came to realize Jessica was leading a double-life as Spider-Woman but chose to stay silent about it. Until a person from said double-life came visiting and almost killed Lindsay. She was Viper and Jessica soon confided about her life to a bedridden Lindsay. Jessica eventually lost her powers but kept at her career as a detective. Lindsay was unable to work away from home due to the lingering effects of her injuries. She took to greeting Jessica's clients and keeping her schedule, effectively acting as her friend's secretary.
Upon full recovery, Lindsay became Jessica's new partner and a detective in her own right. The two spent some time in Madripoor, maintaining a friendly relationship with Wolverine. Jessica regained some of her powers during this period. She has had only minor appearances after leaving Madripoor and the status of her relationship with Jessica remains unknown.