Lady Supreme was brainwashed at the age of 3 to forget her parents for her own safety. She was adopted by a history professor and an amateur model who named her Chelsea Henry. She went to Harvard to study law, but found herself obsessed with fashion. During her teenage years, she found out that Glory and Supreme were her biological parents.
Through time travel and mental transference, she has also adventured as Supreme before regaining her own personality.
In the distant future, Lady Supreme is known as Lady Probable. She is the leader of the Babel-Horolegion, women warriors living in deep space who have abandoned their human forms for starship bodies. They are powered by the corpses of super-powered beings including Supreme's.