Justice League of America appears in 2268 issues.
Member of Hyperclan who adapted a frightful appearance.
One of the Demons Three. Along with Rath and Ghast, Abnegazar used his magical powers for evil purposes.
Member of the Injustice Gang and faced the JLA.
Cosmic villian and would-be universe conqueror.
Battled the Justice League of America in the Silver Age.
The League first encountered Amazo in Brave and Bold #30.
Research pathologist Armen Ikarus was a former employee of Lexcorp who, upon being infected by the Amazo virus, became its living incubator.
Amos Fortune is a villain obsessed with luck who founded and led the Royal Flush Gang at an early age. A gang consisting of Amos' "body guards" from the days he gambled at school. He also discovered the existence of "Luck Glands" and manipulates the luck into his favor.
Angle Man wields the awesome Angler - a triangular device which opens spatial portals allowing him to warp through space.
Anti-Matter Man is a powerful being that came from the anti-matter universe of Qward
Caused the original Crisis on Infinite Earths.
Aquaman Predator is one of the Metapredators. This one is a counterpart of Aquaman.
Justice League of America enemy.
Member of Hyperclan.
Dr. Light is a recurring enemy of the Justice League and the Teen Titans. His mind altering by the JLA changed him from a serious threat to a joke.
Asmodel was one of the four most respected angels in Heaven. However, he rebelled against Heaven and became a servant of Neron.
Atom Predator is one of the Metapredators. This one is a counterpart of Atom.
An ancient God-Monster from the Dark Multiverse. He had first noticed Bruce Wayne when he slipped through time and now has finally arrived in the DC universe.
Batman Predator is one of the Metapredators. This one is a counterpart of Batman.
The Batman Who Laughs is the Dark Knight of Earth -22, and the chosen herald of Barbatos. He was infected by a nanotoxin in the Joker's bloodstream upon his enemy's death, and the combination of the Joker's depravity and Bruce Wayne's tactical mind created the deadliest villain his planet had ever seen.
One of Hal Jordan's oldest foes, Black Hand has evolved from a gimmicky criminal into a sadistic madman capable of siphoning lifeforce from his victims. Reanimated after his suicide, he is now an avatar of the Black Lantern.
Black Manta has fought the Justice League while Aquaman was a member and sometimes without him as well.
Mindless behemoth who was controlled by his brother to commit crimes.
Member of the Killer Elite.
The JLA were on the scene of Brimstone's rampage shortly after Firestorm.
Bruce is Earth's leading scientist in the field of Solar Energy and one of the hosts used by Eclipso.
As a result of swallowing an experimental compound, Byth is permanently able to transform himself into a duplicate of any other living creature he has seen on any planet. He is a native of Thanagar and one of Hawkman and Hawkgirl's archenemies.
Captain Cold is one of the most popular Rogues. He was the second supervillain to ever face the Flash.
He is obsessed with pirates and his pirate themed crimes often brought him into confrontation with Batman.
After Selina Kyle gave birth to her daughter, Holly Robinson is currently the Catwoman.
Two people have taken up the mantle of the Cavalier. The first being a superhero and the other being a villain.
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