Batman, Superman, Green Lantern, Green Arrow and Black Canary are summoned by the JLA alert. They manage to defeat the alien and return the life-energies it stole back to the JLA members. Batman agrees to rejoin the team as its leader. Elsewhere, Zatanna is captured by a cult led by the mysterious Adam. A transformed Despero plots revenge on the JLA.
Terrorists threaten to detonate a nuclear warhead in Gotham City. The Batman subdues the terrorists. The Batman is stunned to hear the old Justice League of America distress signal. Superman douses a fire in Canada. Superman is stunned to hear the old Justice League of America distress signal. The Green Lantern races comets, past Mercury. The Green Lantern is stunned to receive the old Justice League of America distress signal. Oliver Queen raids his refrigerator. Dinah Lance is awakened by the old Justice League of America distress signal, emanating from an old quiver in Queen's closet. Personal crises keep Aquaman, the Atom, the Hawkgirl, and the Hawkman from responding to the distress signal.
A malevolent alien plant disables the distress signal. Cindy Reynolds lives an idyllic life. While on the phone with a friend, Reynolds notices that the image on one of her posters becomes the Vixen. The image of the Vixen moves. The Vixen reaches out and pulls Reynolds into the poster. Reynolds is assaulted by the desiccated corpses of the Justice League of America. Reynolds cries out to her family, who shun her. The Justice League of America melt before Reynolds eyes, begging for her aid. Reynolds wakes up screaming. Lance, as the Black Canary, comforts Reynolds. The Green Lantern scans Steel's withering body. Reynolds explains the situation to the Justice League of America.
The Batman divides the Justice League of America into search teams. Zatanna's investigation into the disappearance of Sheri Stanley leads her to Manhattan's Westside Marina. Zatanna is directed to, and invited aboard, a yacht, "The Regal Leader", where she encounters Stanley. Zatanna is bludgeoned into unconsciousness. Queen, as the Green Arrow, and the Green Lantern, search the Secret Sanctuary. The Green Lantern succumbs to the alien plant's life force drain. The Green Arrow fires a stun arrow into the sinister flora, driving it away. Reynolds blames herself for the current crisis. The Black Canary assures her that it isn't her fault.
Superman discovers the desiccated forms of J'onn J'onzz, the Manhunter From Mars, and Sue Dibny. The Batman reveals that the alien plant was, inadvertently, brought to Earth, as a microscopic spore, by Superman. The spore lay largely dormant, feeding off the life essences of small animals, and insect. Now it is feeding off of the Justice League of America. The plant creature attacks Superman. The Batman retaliates, buying enough time to escape, as does Superman. The Justice League of America re-assembles in the medical center. The Justice League of America confirm that the plant is a psychic vampire that feeds off the life essences of animal life.
Reynolds telepathic powers allowed her to resist the plant's life drain. The Batman concocts a strategy to destroy the plant, and restore the suffering members of the Justice League of America. The Black Canary attacks the creature, then flees, luring it to the Green Arrow. The Green Arrow attacks the creature, then flees, luring it to the Batman. The Batman evades the creature's attack, goading it in to leaping down an open elevator shaft. The creature lands on a series of cables that electrocute it, while simultaneously draining away the life essences of the Justice League of America. Using his own body as a conduit, Superman channels the life energies of the Justice League of America back to the stricken members.
The alien plant burns to death. The crisis over, the all-new Justice League of America spends time speaking with the original members. The Green Arrow and Vibe compare facial hair. The Green Lantern offers advice to Steel. The Elongated Man expresses regret over the absence of the original members. The Martian Manhunter asks the Batman to stay on, as the leader of the all-new Justice League of America. Though it takes a bit of convincing, the Batman agrees. Unbeknownst to all, the Batman harbors ulterior motives for returning to the Justice League of America. Despero emerges from the transformative Flame of Py'Tar, swearing vengeance against the Justice League of America.
- Secret Sanctuary located outside Metropolis.
- Emergency Alert Arrow (signal used to alert Green Arrow) and Stun Arrow used.
- Aquaman, the Atom, Hawkman and Hawkwoman cameo appearances.