Colossus/Jugg in his most destructive aspect almost killed the Red Hulk (overpowered Loeb's Force).
Colossus embodied in the Juggernaut on bloodlust mode nearly killed the Rulk. In this case, is pointed out that Juggernaut/Colossus carried away by his anger (demonic form) was about to kill Rulk swiftly and easily in three punches while a Rulk’s punch (whose maximum force has been measured in 9 Richter’s magnitude) was totally useless against Jugg/Colossus. However, Colossunaught didn't want to snap the pillar which supports Utopia along with Rulk, so he powered down before he was consumed by the bloodlust of Cyttorak’s powers which had turned him in his unstoppable demonic form. In order to avoid killing Rulk along with Utopia, Colossus wanted to self-restrict of the Juggernaut’s powers by allowing himself to be knocked out by Rulk.
Rulk almost killed by Jugg punches
No to mention Jugg (Colossus host) was able to speed blitz and knock down the giant Phalanx one with a simple punch. The Phalanx is techno-organic being which convert organic life forms into himself like a virus which drains their life away.
The Juggernaut (Colossus host) defeated and almost killed the avatar of one of true Asgardian God, the Serpent (even considering that his avatar was powered up by the remnants of Cyttorak’s power). See full detail in: