Vlasco began working for Marvel as an inker in the 1990s, being involved with such titles as Marvel: Shadows and Light, The Uncanny X-Men, and Cable. Along the way, he became a regular inker for penciler José Ladrönn. In addition to Shadows and Light and Cable, Ladrönn and Vlasco worked together on Spider-Boy Team-Up as part of the Amalgam crossover event between DC and Marvel. Vlasco also inked such titles as Superman: President Lex, Batman: Orphans, and Impulse, as well as Cybernary 2.0 and Robotech Sourcebook for WildStorm.
Vlasco's other Marvel credits include Deadpool, Nova, and Contest of Champions, with some of his most recent books being U.S.Avengers, Avengers: No Road Home, Shatterstar, and The Magnificent Ms. Marvel. In addition to Marvel and DC, Vlasco has also worked on Dark Horse Comics' Planet of the Apes and Anarchy Studios' Vampi.
Vlasco died in his hometown of Mexico City, Mexico on April 24th, 2020 due to complications stemming from an appendicitis operation. He was 51 years old.