It's 1957 and even though the times might be different, the life of Dr. Henry Jones Jr. hasn't changed. Indiana Jones is approached by a young college drop out and greaser Mutt Williams about helping his friend and Indy's colleague Dr. Harold Oxley. Oxley has gone missing while searching for the Crystal Skull and mythical city of Akator. Together, along with Indy's pal Mac Mchale and one time flame Marion Williams, they travel to Peru while being chased by Colonel Dr. Irina Spalko and the Soviets and encounter nuclear bombs, Soviets, and giant ants. The adventure will lead to a discovery bigger than time and space itself.