Hope Pezzini was conceived one night when her mother, Sara Pezzini, was comatose in the hospital after a battle using the Witchblade. Jackie Estacado, who was being possessed by the Darkness itself at that time, took Estacado's body to the hospital and the two unconscious adults had sexual intercourse. Sometime later after her awakening Sara realized she was pregnant despite having no memory of the act and claiming not to have slept with anyone for over a year. Wishing to give her child a safer life Sara gave the Witchblade to Danielle Baptiste. Shortly after that she went on maternity leave from the NYPD.
Shortly before Sara was due she was visited by Jackie Estacado who claimed that he was in fact the father of her unborn child. Sara knew that this should be impossible due to the curse of the Darkness. Jackie had recently learned from an Angelus Warrior that the scales in the war between the Darkness & Angelus were being tipped in favor of the Darkness, and that the child was the cause of this.
Dani crashed through the window during the discussion and revealed that the Angelus and her host of warriors were right behind her. Patrick Gleason, Sara's partner & lover was injured while the duo fled the ruins of Sara's apartment. Jackie held off the Angelus (who had recently acquired a new host in Celestine Wright) and after creating a diversion fled with Sara and Dani. The trio traveled to one of Jackie's safehouses and there they were joined by Patience, the Magdalena. While Jackie and Magdalena fended off the Angelus, Danielle Baptiste helped deliver Sara's baby. Sara gave birth to a baby girl that she eventually names is Hope after her grandmother.
Sara had a hard delivery and Danielle noticed Sara was loosing a large amounts of blood. Sara passes out almost immediately after giving birth to Hope. However, the Witchblade restores her life by dividing the power of the Witchblade between Dani and Sara, and she walks outside carrying her newborn baby. She confronts the Angelus, who then hits Sara and takes the baby away from her. Hope then displays some kind of power that causes the Angelus and all her minions to disappear. Now that Sara, Hope, Dani, Jackie, and Magdalena are safe, Jackie leaves but tells Sara that if she or the baby ever needed, he'd be there, he then kisses her and leaves. Hope stays with Sara, who now can protect her with the power of the Witchblade.
Hope had recently met her Aunt Julie (Sara's younger sister) and Julie moved in with Sara and Hope (after Hope gave her approval of Julie).
While she was with Julie Pezzini on a park, Aphrodite IV appeared, killed her Aunt and after a brief battle with a Darkling and an Angelus Warrior that were in charge of watching over her for The Darkness and The Angelus, took of with Hope. It is later later realized the Curator has planned to gather all 13 Artifacts then sacrifice Hope and the Top Cow Universe to recreate his original universe; a universe he partially responsible for destroying. He did destroy the Top Cow universe, but was killed by Sara and Jackie before he could kill Hope. This left Sara, Jackie, and Hope left in a blank existence, where Sara was left with no choice but to sacrifice Hope to recreate the universe.
The Estacado Family
At the end of Artifacts it was up to Hope parents, Sara Pezzini and Jackie Estacado, recreate the universe, and He created his ideal family with his lost love Jenny Romano as his wife and an older Hope as his daughter.
Sara Pezzini: Mother [Bearer of the Witchblade]
Jackie Estacado: Father [The Darkeness]
Jenny Romano: Mother [Post Artifacts event]
Julie Pezzini: Maternal Aunt
Capris Castiglione: Paternal Aunt [Darkness Weilder]