There are no current statements from the makers of Gears of War that there will be another sequel. Game creater, Cliff Bleszinski, stated,
"No comment about a sequel, and no comment that this game series will be a trilogy or not."
As for the Carmine brothers, there could be 2 in the next game, seeing as how there are 2 left, but I'm sure that's not even on the mind of Bleszinski. We'll just have to wait and see how many Carmines we can kill in the next game, if there will be one.
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