Comics are male dominated, and women historically haven't played as large a role as the guys. The face of that has been changing but there are still plenty of ladies that are getting slept on.
Choose a female character and re-imagine her. It could be her powers, her status and backstory, her attitude and vision, her outfit. It could be anything but it is your job to make her a frontrunner just as sought after as the big fellas like Spide, Supes and Spawn.
Alright get to creating.