I don't think they will fare well against the imperium or the other forces.
First off, how many are we talking about here? ten? Hundreds? Thousands? You'll have to give the predators numbers around hundreds of thousands so they can have a chance at it.
Now I assume the world they're going to drop in is an imperium world. Even if they manage to fully eradicate the local population and increase their forces, they will have to do so against multiple other worlds and gain a foothold in a sector before the imperium catches wind of this new intruder and gets to launching full assault against the invaded worlds or quite possibly performing exterminatus. Now, against imperial guard forces then they can stand a chance of eliminating them but this is a big IF since the imperial guard are numerous and can employ the use of very heavy artillery and tanks to overwhelm their foe.
Space marines I don't see the predator weapons managing to take down. Though I may be wrong.
Orkz are just impossibly hard to eradicate and will win through attrition.
Eldars employ the same kind of tech the predators have but on a much grander scale.
Same for the Tau
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