Madara does have Hashimaru's cell, but is not in edo tensai, but he has the rinnagen
Whitebeard is in his prime ready to rek some crap up
Winner by K.O
Whiteboard (im going off the old man) because:
1) Genjutsu doesn't work on those without chakra. Madara's greatest asset would become void and if he's unaware of this he will end up getting hit with a quake
2) Without the reanimation jutsu to protect and regenerate his body won't be able to survive the big moves like the meteor strike (even he admitted that the move was only useful because he could not die).
3) Without the unlimited chakra he'd either need to go all out from the start and how he doesn't run out or try to outlast Whitebeard which I can't see happening
4) Due to haki Whitebeards reactions are better than Madara's period. He's able to fight an admiral who can move at light speed in combat!
As for Susanno which will inevitably be brought up, there's no reason to say it's barriers would hold up to multiple quakes. A holding back Whitebeard devastated/destroyed an island, even if we take him as just island level his Susanno takes energy (like all ninjutsu abilities) and a finite amount of chakra will either force Madara to make it significantly smaller or he'll get it caved in.
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