Now thats a good question. Although I doubt Ghost Rider would last long enough to get that close to Thanos. But if he did... I'm guessing that the penance stare might drive the mad titan even madder.
Penance Stare won't work on someone who has a warped sense of reality, like Thanos or Super Skrull. Therefore, Ghost Rider's strongest ability has been taken away, so that just leaves hand-to-hand combat, which Thanos would win.
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