This would actually be an interesting match. If, judging by the OP image, we're using Resident Evil 5 Jill Valentine, her physical enhancements make her incredibly swift, complimenting her skill in combat. Comparing feats, Castle definitely has more impressive showings, for sure, but I have no doubt that Jill would put up a hell of a fight. For reference of what Jill is capable of, this is a video of her capability.
@progenitorigin: Maybe Jill was heavily treated with strenght enhancement virus, but Frank is a strong as Chris Redfield. Here’s an example of his feat of strength by killing someone with ease after being severely tortured https://youtu.be/V8G3jHhZZLg
@allstarsuperman: You’re missing the point. Earth-95126 Frank Castle has the exact same skills from Frank of the MCU and Earth-616. If he faced Jill from Resident Evil 5, I don’t know who would be left standing.
First. Fighting techniques. Under his real name Francis Castiglione, Frank is a Vietnam era US-Marine. Marines from Frank’s time were trained in Linear Infighting Neural Override Engagemen fighting system (LINE) not MCMAP. Tough same rules apply (one mind any weapon) the LINE system was designed to strategic killing. Jill would be outmatched. (See this video: https://youtu.be/KZlJSS13iQs )
Second. In Resident Evil 5 Jill beat Chris because he wasn’t trying to kill her. In Frank’s mentality, if you’re an enemy, you die. (See his work: https://youtu.be/qEHkfnlrlas and https://m.youtube.com/watch?v=RWaVz2wVQCc&t=156s )