Luke Cage stomps. After his amps in S2, there's no doubt that he is more physically powerful then Captain America, Winter Soldier, and Black Panther. Those are all super soldiers with years of intense training and combat to strengthen them to the max. Peak super soldiers if you will.
Blonsky was good but he was only a super soldier for a few weeks. He doesn't really even have any strength feats. Basically I don't see him putting Cage down in hand-to-hand. It's not like Cage isn't very skilled and competent as well.