None of the opponents really compare to them, IMO.
Loki is powerful but he could never do the same kind of things that Thanos has done like fighting Odin for 10+ pages without going down. Similarly, Darkseid has matter manipulation/reality-warping feats on the same tier as Loki but is undeniably much stronger, more durable and faster.
I haven't read much stuff with Klarion but I always considered him a mid-tier on an average situation, needing prep to go above that.
Spawn is weird but as far as I know without amps like being God Spawn or an Hell King, he also doesn't come close to the teambuster tier. His rivals in power like Angela and the Violator are basically mid-tiers.
Ghost Rider is the only one here whose power can give either Thanos or Darkseid some trouble, but both of them have fought and defeated similar beings quite casually.
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