The Saint of Killers and Dr. Manhattanare easily the two most powerful entities in either of their respective universes, they in fact are two of the most powerful human beings conceived in comics.
The "Preacher"s' Saint of killers is high dogmatic being who derives his powers from the word and logic of God. In the the "Preacher" Series the Saint of killers, upon having a heart cold enough to freez hell the Saint of killers got the attention of satan and the angel of death. The two of them, afraid of the man who's heart was cold enough to freeze over hell, offered to make him the new angel of death or saint of killers. Satan personally crafted two revolvers out of the sword of the angel of death and imbued them with the powers to never miss a target, never deal anything but a lethal blow, and never run out of bullets. The saint of killers has used the weopens to kill entire villages, armies, tanks, satan and even god himself. He is also immortal, and has survived bullets wounds, artilery and even nuclear bombs.

Dr. Manhattan is a high metaphysical being. Disintegrated by an intrinsic field separator Dr. Manhattan (john osterman) was able to reconstruct himself by memory and become an immensely powerful creature that could change the nature of reality himself. His power of space, time, causality, property and probability make him powerful enough to create any object he desire or destroy anything he sees. His powers are shown to be near limitless.

The question than of course is could Dr. Manhattan change the nature of reality enough to avoid a bullet from the saint of killers.. Dr. Manhattan can change the nature of reality itself, he possibly could change the composition of a bullet rendering satans creed of "No shot they fired would miss its mark". Could he perhaps time travel backwards to avoid the shot. Could he change himself into nothing into something dead like a rock? And even so could he deal any damage to the immortal "Saint of killers"?
It's the laws of science versus the law's of god, so what do you think
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