Tamara worked with Ezekiel Sims as an associate, and together they monitored Cindy Moon after she got her powers. Over the years after Ezekiel's passing Tamara took on the identity of Fang and used the newly inherited wealth to build her own empire and used the funding to try and recreate Cindy's powers.
Using some sort of injection on Albert Moon she was able to sway him even more to her way of thinking that Cindy's powers needed to be removed and that they needed to find a cure. That's when Fang sent Albert and Nari into the Negative Zone to obtain the final ingredient a strange blue substance.
After receiving the final ingredient Fang constructed the "cure". In actuality the cure was nothing more than the transferal of powers. Cindy learned all of this while working with S.H.I.E.L.D. After confronting her father outside of Tamara's building about what he had been doing that's when Fang attacked Cindy with a small army of piloted mechs. Fang thought Cindy had wasted her gifts and wanted to use the "cure" to take what she felt was hers.
Silk using the knowledge obtained by S.H.I.E.L.D. and with the help of her boyfriend Spectro the two were able to defeat Fang. Spectro disabled Fang's electronics while Silk took on Fang directly. Afterward S.H.I.E.L.D. came in to detained her.