When Achira, a disease-spreading entity, is released by a group of subway workers, former Ghostbuster Egon Spengler, now a professor teaching paranormal studies at a New York college, attempts to handle the situation alone. When he fails, his only option is to round up the (only four) students in his class to be the next team of Ghostbusters - but one of them has already fallen to Achira.
- Egon Spengler - Maurice LaMarche
- Janine Melnitz - Pat Musick
- Kylie Griffin - Tara Charendoff
- Eduardo Rivera - Rino Romano
- Roland Jackson - Alfonso Ribeiro
- Garrett Miller - Jason Marsden
- Slimer - Billy West