Drug use in comics usually takes the form of abuse through minor characters associated with major characters. Well known exceptions to this are Tony Stark's battle with alcohol and Roy Harper's battle with heroin. Certain other drugs are occasionally portrayed as well, including fictional ones such as venom (which Batman broke a dependence on at one point.)
Drugs are one of the aspects of crime which is continually displayed accurately, as not only does the use of drugs have negative social, psychological, and physiological effects on the user, but that the use of drugs facilitates international cartels of suppliers and adds significantly to street crime.
Throughout the years, many anti-drug advertisments and public service announcements have appeared in the pages of comics. Spider-Man is often used in anti-drug (as well as other PSAs), many of which have been collected in Spider-Man Fights Substance Abuse.
The White House Office of National Drug Control Policy teamed up with Marvel Comics to make a four part anti-drug campaign with Spider-Man as the main hero known as Marvel Comics' Fast Lane. It was published in many Marvel comics as well as magazines throughout 1999-2000.