Every human on earth is turned to stone by a mysterious phenomenon, including high school student Taiju. Nearly 3,700 years later, Taiju awakens and finds his friend Senku, who revived a bit earlier. Together, they vow to restore civilization, but Tsukasa, once considered the strongest high schooler alive, nearly kills Senku in order to put a stop to his scientific plans.
After being secretly revived by his friends, Senku arrives at Ishigami Village. But when word of Senku's survival gets back to Tsukasa, the war between the two forces begins! Eventually, the two factions make peace. After acquiring a petrification device on Treasure Island, Senku heads for the U.S.A. to find corn and encounters another science kingdom!
Stanley's vicious pursuit ends with what seems to be the deaths of nearly everyone in the Kingdom of Science. However, the team manages to activate a working Medusa device and petrifies the entire world again. Luckily, Senku devises a clever scheme to revive Suika in the aftermath. After working hard all by her lonesome for seven years, Suika manages to re-create the revival fluid and frees Senku.