Horace Littleton was a scientist for the Weapon Plus program in the 60's, and eventually developed a LSD/Super Soldier Serum hybrid. However, Littleton's project had lost funding as well as test subjects so, Littleton injected the serum into himself.
Powers and Abilities
Dr. Mindbubble gets his power from a bowler hat he wears which has a pipe that comes out the front. The pipe creates large bubbles which, when encapsulating the head of a person, causes them to enter a mind-altering state. It has been shown that the only way for a subject to escape the consciousness-altering mind bubble and pop it altogether, is to kill yourself in the dream state.