Character » Doctor Octopus appears in 2442 issues.
Edward Nigma is a villain obsessed with riddles, puzzles, and brain teasers, who took the alias of the Riddler to commit crimes. Riddler frequently tries to outsmart Gotham's hero Batman, but is always defeated by the Dark Knight.
Rosalie Octavius was the wife of Dr. Octopus in Spider-Man 2 movie.
Sajani worked in Horizon Labs and currently, in Parker Industries. She is the creator of the Reverbium.
Doctor Octopus recruits Sandman and four other villains to join his Sinister Six team, so that Spiderman can finally be defeated.
MacDonald "Mac" Gargan was a failing private investigator that was turned into the Scorpion with financial help from J. Jonah Jameson. He became a host of the Venom symbiote and was part of Norman Osborn's Dark Avengers. After the US Government took the symbiote, he became The Scorpion once again.
Created the Parker clones in Ultimate Universe.
A demon that took over the body of mercenary and Spider-man villain Override. He later took over the body of another man, Gray Dolman.
A fellow member of the Civil War Sinister Six.
Helped Doctor Octopus when he was Superior Spider-Man
Peni Parker is a 14 year old girl and pilot of a mech suit called SP//dr. The machine only responds to the pilot that has the right DNA. In the mech suit's head, there is a radioactive spider that shares a psychic link with the pilot.
Mechanical arachnid designed by The Superior Spider-Man (Doctor Octopus).
Spider-Boy is a combination of Ben Reilly and Superboy from the Amalgam Universe.
A young woman who acts as a superhero in an online world
Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
Dr. Jamoff "Max" Borne is the Spider-Man of the year 2211. He is part of a future organization called the Time-Spinners, which seeks to prevent disruptions in the time field, and prevent any imbalance in the mainstream universe. He was killed by the Chameleon of 2211.
One of several japanese Spider-Men.
Fellow Web Warrior
Former Captain Britain Corps member, originated from Earth-833. After the Captain Britain Corps was seemingly lost and his universe wiped out by an incursion Spider-UK created the multiverse traveling group known as the Web Warriors and is its leader.
Anna May Parker, called Annie as a nickname, is the daughter of Peter Parker and Mary Jane on Earth-18119. She inherited her spider powers from her father and now fights crime alongside her parents as Spiderling.
A cluster of radioactive spiders with Peter Parker's consciousness. Joined then betrayed Superior Spider-Army (Spider Force).
A former lover of Doctor Octopus and enemy of Spider-Man who uses virtual reality to become her alter-ego.
Sunset Bain is a ruthless businesswoman and a major enemy to Iron Man and Machine Man.
The Spider-Man from the 1978 Toei TV series. He has a giant robot called Leopardon.
Former Avenger and Captain Universe. She was granted her power after a car crash.
A hit man with an angle, a costumed villain with the solution, he is The Answer!
was one of the villains under his command during the 1985 incident.
The cold, tall and monsterous looking Spider-Man villain who takes pride in his grim and death-like appearance, Lonnie Thompson Lincoln is a criminal enforcer who uses methods of intimidation and murder under the deserving nickname of Tombstone.
Torbert is Doc Ock's father
Titania's best friend and ex-girlfriend of Molecule Man.
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