Character » Doctor Octopus appears in 2439 issues.
Doctor Octopus recruits Electro to join his new Sinister Six team. Their goal is to finally defeat Spiderman.
Elias Hargrove is Dr. Octopus' cousin.
Weasel worked for Dr. Octopus.
Sylvia Prell was a college student in New York till she got affected by the Terrigen Mists. She became a being of pure energy and Spider-Man helped her to control her powers.
Gog is a Tslin that was discovered by Kraven the Hunter who named him after a Biblical giant. Kraven used Gog to help build a kingdom in the Savage Land. Gog has had runs in with Spider-man, Ka-Zar and Hercules, Even being as muscle in the third incarnation of the Sinister Six. Later on it's revealed that Gog was a family pet, that was sent to Earth from a dying world.
A fellow member of the Civil War Sinister Six.
A costume-wearing criminal who is rumored to have cannibalistic tendencies. He went on to join the Masters of Evil and was later appointed to Norman Osborn's Thunderbolts squad to aid them during the Siege of Asgard.
The youngest member of the original X-Men. Bobby is an Omega-level mutant, although it took some help from Emma Frost to realize this. Bobby's control of ice is vast; he can create shields, clones, spikes, slides and also freeze others. He was recently elected to Krakoa's X-Men
Jason Philip Macendale, former agent of CIA, turned from the first Jack O'Lantern to the second major Hobgoblin and once the host of Demogoblin. He was rebuilt as a cyborg and remained Hobgoblin until the first Hobgoblin who was thought dead returned and killed him.
Jean Grey was one of the five original X-Men. An omega-level mutant telepath and powerful telekinetic, Jean has gained near limitless powers as a recurrent host of the Phoenix Force. She is known for her return from death and as the wife of Cyclops.
A member of the inheritors and brother to Morlun, Karn hunts down Spider totems to redeem himself in the eyes of his family.
Kingmaker is a demon entity that feeds on human memories. He has interacted with numerous individuals, most recently conflicting with the Hellions.
The Kingpin is a supervillain originating from Marvel Comics. The self-proclaimed kingpin of crime, Wilson Fisk is one of the most prominent figures of organized crime in the United States. He is the king of mobsters, controlling organized crime on the East Coast with an iron fist. Kingpin is a major enemy of superheroes Spider-Man and Daredevil.
A former Assistant District Attorney of New York City currently working at Nelson and Murdock law firm.
A fellow member of the original Sinister Six.
Otto Octavius' apprentice, who took the title of her mentor after Octavius' death, and has fought Spider-Man many times.
Recruited him for the Sinister Six during Sinister War
I.C.M. built a computer in the form of a human body in order to dramatize its powers. It was the greatest mechanical brain ever built. It has been recently seen as the newest member of the Sinister Six.
Mary Alice and Dr. Octopus were engaged to be wed.
Mother of Dr. Octopus
Reed Richards, also known as Mr. Fantastic, is the leader of the Fantastic Four. He can stretch his body to great distances due to his exposure to cosmic rays while in space. He is also considered to be one of the smartest men alive, using his brain to explore alternate dimensions and save the world alongside his family from science-based threats.
Doctor Octopus was a member of the original Sinister Six, along with Mysterio.
A new person wearing the equipment of the original Mysterio who bought the rights to use the name from Hobgoblin.
A villain who uses nanites to alter motor vehicles to his liking. Formerly working for Mr. Negative, he is now a member of the Sinister Six.
The Spider-Man of Earth-50101. He has similar powers as the Earth-616 Spider-Man, except his powers are magical in nature.
A long-time archenemy of Captain America, Johann Schmidt is a proud Nazi general and the embodiment of evil, fear, and horror. He is known as the ruthless Red Skull.
The omnipotent ruler of the Regency who slaughtered all of its superheroes and harvested their powers years ago.
A career criminal, the man known as Rhino has incredible strength and durability. A long-time enemy of Spider-Man and the Incredible Hulk, Rhino isn't particularly malicious, and has tried on various occasions to leave behind his life of crime, but always seems to slide back into old habits.
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