Doctor Locke appears in 6 issues.
When they first met, Madorx promised to kill Doctor Locke as he'd discovered that the Doctor was responsible for brainwashing Strong Guy into being an unconscious murderer. Doctor Locke used a machine that stimulated Madrox's brain into torturing himself (with the illusion that his parents were torturing him). However, the mental stimulation continued when the machine was switched off, and Madrox began to punish himself by slapping himself across the face. The ensuing crowd of duplicates crushed all Hydra agents in the building, including Doctor Locke.
Although they'd never been shown together in the comics, it was established in X-Factor #15 that Doctor Locke was the man responsible for brainwashing Strong Guy into becoming a sleeper agent & unconscious murderer for Singularity Investigations.
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