As I recall, the only way to kill someone with a healing factor is to cut their oxygen supply. Which can achievable by cutting one’s head, for example.

In the Deadpool first series, Thanos wouldn’t let Wade die. Since the Titan was also in love with Death, he cursed the merc with life itself, rendering him immortality. Yet, there’ve been a decade since he last appeared in a Deadpool comic, or was even mentioned, making us wonder, did marvel forget their own storyline?

Now days the writers apply the healing factor itself as the reason Deadpool can’t die, and it’s ridiculous because it makes not only Wade, but Wolverine, Agent X and much others invincible. He restored himself from a headshot and an utterly body explosion induced by a vicious case of HULK SMASH.

I want to know if I’m missing something, because the idea of an army of immortal characters doesn’t sound very pleasing to me.

Can anyone explain me if DP can die and How? Or maybe the one missing something is Marvel itself.

Well there was this one time he died fighting thunderbolts!( head cut off) but he came back to life after black widow sowed his head back on, so I guess he could die, but the real question is, will Marvel kill Deadpool (forever)? and the answer is no.

Well there was this one time he died fighting thunderbolts!( head cut off) but he came back to life after black widow sowed his head back on, so I guess he could die, but the real question is, will Marvel kill Deadpool (forever)? and the answer is no.

Deadpool should essentially be immune to death, all of these instances with his head seem to be inconsistent since he has regenerated his head before.

Locking- dupe thread http://www.comicvine.com/deadpool/29-7606/can-deadpool-die/92-639781/#5