Deadpool appears in 2845 issues.
The 16th President of the United States.
An extremely violent boxer turned criminal, Loki bestowed his powers upon him, and he was transformed into the Absorbing Man, granting him powers to absorb any material and take on its properties. He is the on-again-off-again husband of Titania, and an enemy of Thor and Hulk.
A Wakandan who sold his soul to the devil and hired Wade.
Leader of the Watchtower; an anti-mutant faction. Killed by an alternate future version of Domino
The man who ruled over Nazi Germany during World War II. He wished to wipe leftists, Jews and other "inferiors" from the planet and rule over the world propagating an Aryan race agenda, an ideal that he oddly did not fall into himself.
An agent of S.H.I.E.L.D. who stiffed Deadpool on a payment for the mission to kill resurrected presidents of United States.
Head of security for the weapons manufacturing company GenForm Enterprises.
A clone of Deadpool and Black Swan that has been both friend and foe to Deadpool
Ajax tormented Deadpool at the Weapon-X hospice. He was thought killed by Deadpool, but returned, only to be truly killed by Deadpool.
FBI agent crippled by Deadpool
A crime lord in conflict with Farouk.
One of Magneto`s mutant creations in The Savage Land. A member of The Savage Land Mutates. Amphibius is a batrachanthrope (Were-Frog) or a human/frog hybrid. He has the leg strength and nautical abilities of a frog.
From Little Women.
Member of a version of Six Pack that targeted Cable
Ananastasia prefers to be called Anna and works at a tattoo parlor, and has links with the mob. Deadpool meets the gorgeous Anna, and falls in love with her.
Former terrorist and son of HYDRA's Baron Strucker, Andreas von Strucker abandoned his life of evil following the death of his sister. Choosing to become a better man, he became the superhero Swordsman and joined the Thunderbolts on his quest to be the opposite of everything he'd been before.
In the first Deadpool movie, Angel Dust was a heavy for Weapon X
One of the very first mutants, Apocalypse is both thousands of years old and a monstrous tyrant that has been a longtime foe of the X-Men. Apocalypse believes that only the strongest (whether mutant or superhuman) should survive. His body is a mix of organics and powerful celestial technology, boosting his shapeshifting and other powers to god-like levels.
One of the Three Musketeers.
Seeking challenges, Arcade has tested the abilities of many superheroes in the Marvel Universe. Trapped inside his dangerous Murderworlds and playing to survive, always nothing more than just a game for Arcade.
Scientist Arnim Zola became one of the first biochemists in history after finding notes and equipment belonging to the offshoot race of humanity, the Deviants. He learned many things from his studies, including the ability to transfer people's essence into clones of their original bodies.
An Asbury Park lifeguard with aquatic powers who sold his soul to Vetis.
Ashcroft was an A.I.M. Agent under Sub-Cmmander Blake. Ashcroft was eventually killed by Zombies, in the Zombiverse.
Satana hires Deadpool to help find her immortal soul. Deadpool comes into conflict with several big time demons including Asmodeus because whoever controls Satana is heir to Hell. Deadpool marries Satana and she fuses his katana with hellfire. During a fight with Asmodeus, Deadpool slices him in half.
Created by Apocalypse, fought Namor in a submarine.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
The Awareness is a mind-absorbing, world-conquering, powerful being who has taken control over several thousands of worlds.
A synthetic adaptive android designed by the Mad Thinker to combat super-heroes. Although later defecting and becoming an employee of Goodman, Lieber, Kurtzberg and Holliway.
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