When Dracula hires Deadpool to transport a highly-valuable delivery for him, he has no idea what kind of trouble he's in for. Guest-starring Blade, M.O.D.O.K., Hydra Bob, Werewolf by Night, and more-hop on with Deadpool for a crazy journey across the world...and into the heart of the Merc with the Mouth!
Hydra's submarine has been sucked into a tractor beam by A.I.M. Hydra Bob swears that he didn't sell Deadpool and Shiklah out. They are confronted by A.I.M. Bob who is apparently immune to Shiklah's powers. He isn't immune, however, to watching a small monster ride around on a Rumba. He realizes the distraction too late and get walloped and then kissed by Shiklah. Deadpool mentions that she didn't have to kiss A.I.M. Bob and Shiklah notes a hint of jealousy in Deadpool's voice. She moves on and takes out the A.I.M. henchmen herself while Deadpool follows in her wake with Hydra Bob. Hydra Bob gets the distinct impression that Deadpool is falling for Shiklah. The two find her standing victorious on a heap of A.I.M. henchmen. The reunion is short-lived, as M.O.D.O.K. arrives and captures Shiklah in his tractor beam. He intends on slicing her up to find the source of her powers. M.O.D.O.K. exits the the Hydra submarine via his ship's tractor beam. Deadpool wafts a grenade into the tractor beam that zooms into the A.I.M. ship.
With the tractor beam dismantled (as well as the A.I.M. ship) everyone falls to the earth. A.I.M. henchmen hit the ground, but Deadpool evicts M.O.D.O.K. from his chair and floats down with Shiklah and Hydra Bob. Unfortunately, Hydra Bob can't hold on and falls the rest of the way down. He breaks his legs and Deadpool has to knock him out to get him to the doctor.
Elsewhere, a captive Werewolf By Night is fitted with a collar and is ordered to kill Deadpool and bring Shiklah to Dracula.
Being a man of a sundry reputation, Deadpool takes Hydra Bob to a veterinarian to get fixed up. With a lie about being Captain Britain 2099, plus a wad of cash, the vet does whatever Deadpool asks in regards to the care for Bob.
Deadpool and Shiklah leave and enjoy the evening air. Shiklah thinks that the setting is almost romantic. Werewolf By Night then leaps from the shadows and attacks the two. Shiklah runs into an old manor to find some silver while Deadpool fights the beast. Deadpool appears to fail, as Werewolf By Night finds Shiklah in the house and attacks her before she can change into her monster form. Deadpool arrives dressed in armor and defends Shiklah. She sees a vampire collar on Werewolf By Night and blasts it from his neck. He comes around and states that Dracula ordered him to attack Shiklah. He also overheard that Shiklah's brothers are alive, which shocks her, as she presumed them dead.
At Dracula's mansion, Dracula is fed up with Shiklah's brothers. He leaves them to watch television while he assembles his Frightful Four: Frankenstein's Creation, the Mummy, Xzax, and Marcus, Centaur Warrior. He orders these monsters to find and kill Deadpool.