Despair is contagious . . . and so is death! Fed up with the lack of bloodthirst from his captives, Monokuma infects them with the Despair Disease. Afraid they could commit murder while not in their right mind, the sick students are quarantined . . . but the killing hasn't stopped!
- Chapter 14: Beliefs of the Guilty (Culprit)
- Chapter 15: After the Trial
- Chapter 16: Feelings of the Surviving Students
- Chapter 17: Despair Disease
- Chapter 18: Desperate Nursing
- Chapter 19: The Third Murder