Based on the 1993 Argentine comic book series of the same name.
The series debuted in Canada and Argentina on September 6, 1999, and was subsequently dubbed for French, Japanese, Malaysian, Polish, South American, Spanish and Thai viewers. It was animated by Tokyo Movie Shinsha and NOA; produced by Herve Bedard, Toshihiko Masuda, and Koji Takeuchi; with storyboards by Atsuko Tanaka, Hiroyuki Aoyama, Nabuo Tomizawa, and Kazuhide Tomonag; and written by Catherine Girczyc, Carlos Meglia, and Carlos Trillo. Original music was composed by Robbi Finkel, and character designs were overseen by Teiichi Takiguchi. This show aimed at children by toning down the comics' darker themes.
The title sequence and closing credits featured lyrics written by Robert Olivier, which were sung by jazz vocalist Coral Egan.
On April 28, 2001, Cybersix won "Special Mention for the Best Science Fiction Program" at the Pulcinella Awards in Italy.