Cancer was a Life Model Decoy created by Scorpio (Jacob Fury) in his "Theatre Of Genetics" to be part of his Zodiac crime organization. Scorpio went after his brother, Nick Fury, with his new group, but was defeated by Defenders and Moon Knight. The Zodiac LMD's were recruited by Quicksilver during his bout with temporary insanity, and Quicksilver ordered the Zodiac LMD's to destroy Avengers for their imagined wrong doings. The Avengers managed to defeat the group and most were remanded into federal custody.
The android Zodiac were soon released, and the Scorpio LMD rebuilt a number of them. Scorpio used the Zodiac Key to create LMDs that exemplified the forces and personalities inherent in each sign, hoping to create great strength in the combination of all twelve traits of the Zodiac. He arranged the ambush in which the android Zodiac killed all of the remaining human Zodiac leaders except Cornelius van Lunt, alias Taurus. Immediately afterward, Van Lunt sought out the services of the Avengers' West Coast branch to confront and defeat the android Zodiac. In their initial foray, the Avengers failed, although several androids were destroyed.
The Zodiac Key immediately resurrected the Scorpio LMD. Claiming superiority and believing that the Zodiac would eventually kill the Avengers as the androids could never be stopped, Scorpio wanted to use the Key to transport everyone on the scene to the Key's native dimension where the conflict, he believed, could be prolonged indefinitely. However, when the androids were in the other dimension, they ceased to function because each of them were aligned with a particular zodiacal energy, energy that did not exist in the other dimension. The Avengers found Hawkeye and Tigra had been sent to the same dimension and, reunited, the team was sent back to Earth by the Brotherhood. However, secretly the Brotherhood waited so that someday they could also send the Key to Earth again and create new conflicts for them.
This Cancer has enhanced strength and endurance and an armored shell that provides some protection from physical and energy attacks. He can project powerful jets of water from its hands and has a set of pincers which he can use as a weapon.