Liz Sherman blew up the center of the earth to stop the spread of the frog men with which the Black Flame planned to overrun the world. Although she killed that Black Flame, the devastation Liz wrought brought about a new Black Flame and a more terrifying worldwide wave of monsters. Facing an uncertain future, the BPRD count up their casualties as Hell on Earth comes to a close.
This is the end of the Hell On Earth story cycle, as well as the final issue in John Arcudi's 12 year run on the BPRD titles.
The epilogue of this issue takes place simultaneously with Abe Sapien #36 was also the final issue of that series. The two issues were intended to come out around the same time, but due to delays involving the "The Exorcist" story arc of BPRD Hell On Earth, the two series finales came out months apart.