Picking up where #3 left off, Batman begins combating several of his biggest foes at once, thanks to Jeremiah Arkham. He quickly dispatches them without too much damage to himself as Arkham watches. Meanwhile Nightwing continues to look into how Zsasz can be committing these murders, and why. Eventually Batman and Nightwing confront Zsasz while he is trying to return to Arkham. They defeat him and he is returned to his cell, which he will no longer be able to escape. The issue ends with Jeremiah wondering if he will turn out like his uncle, locked in his own Asylum.