A fanatical Middle-Eastern Sect leader, a pyromaniac Italian assassin, and a gaggle of ninja nuns chase Armstrong and his partner into the Sistine Chapel. They'll take the immortal's head if they have to burn the whole place down to do it! Meanwhile, back home in L.A., Armstrong's mysterious satchel of forbidden treasures falls from one set of wrong hands into another!
Surrounded on all sides by the insidious Sect, Archer and Armstrong attempt to escape from thr Sistine Chapel! While the trigger-happy Sisters of Doom give chase, Mahmud struggles to stop Constantino from bringing his flame-thrower to bear within the holy building! Slipping away disguised as the ninja nuns, Archer and Armstrong leave Mahmud to be burned by the crazy Constantino.