Kaine met Annabelle when he went for a drink in the Four Seasons Hotel bar where she worked as a bartender. The two have developed a rocky friendship and she is one of the few people that is aware Kaine is also the Scarlet Spider.
Annabelle is not all she appears and was seen burning a letter of warning sent by Madame Webb to Kaine, warning him of an impeding danger before the he could see it. Annabelle's true intentions have yet to be seen. It has been hinted she may be the Totem Eater Shathra in disguise.