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Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
The amoral industrialist Norman Osborn was transformed by an experimental serum into the maniacal Green Goblin, and has endured over the decades as Spider-Man's most dreaded archenemy. Osborn is known for being the killer of Gwen Stacy, the architect of the Clone Saga, and the one-time director of S.H.I.E.L.D.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
Peter Parker's friend since college and Robbie Robertson's son.
The White Rabbit is a young woman with a dangerous obsession with Lewis Carroll. She is an enemy of Spider-Man.
The cold, tall and monsterous looking Spider-Man villain who takes pride in his grim and death-like appearance, Lonnie Thompson Lincoln is a criminal enforcer who uses methods of intimidation and murder under the deserving nickname of Tombstone.
Paul is a time traveler and the caretaker of two children being hunted down by an alternate version of his father, Dr. Benjamin Rabin. He is responsible for the destruction of his Earth.
Janice Lincoln, daughter to the mobster Tombstone, is the current Beetle, formerly a member of Boomerang's Sinister Six, and now the leader of an all-new Sinister Syndicate.
Raised as a wealthy socialite, Whitney Frost was initially horrified to learn of her true heritage as the daughter of the Maggia-leader Count Nefaria. Hiding her face behind a golden mask after horrible scarring, she has been driven mostly by vengeance against her father which has placed her on both sides of the law.
Former cat burglar Felicia Hardy became a crime fighter when she became romantically attracted to and involved with Spider-Man. Felicia has the ability to instill "bad luck" around others - this comes in handy when fighting crime!
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Editor-in-Chief of the Daily Bugle, and perhaps the best friend to J. Jonah Jameson.
Enforcer for Tombstone's gang
After he was resurrected, Kraven convinced the High Evolutionary to create 87 clones of himself. This last clone hunted and killed his 86 brothers to become Kraven's sole heir, and after killing his "father," he became the new Kraven the Hunter.
A polymorphic Muslim Pakistani-American teenager from New Jersey. She becomes the newest holder of the Ms. Marvel identity. She is the Inhuman leader and one of the founding members of the adolescent superhero team the champions.
A small time criminal that worked his way up to having his own crime family within the Maggia.
Doctor Octopus is a supervillain originating from Marvel Comics. A former nuclear physicist and atomic researcher, Otto Octavius' life changed forever when one of his experiments went horribly wrong involving his four mechanical appendages used to assist him in his experiments. From then on, Octavius soon after his initial encounter has become one of the most dangerous supervillains in the Marvel Universe.
Madelyne Pryor is Cyclops's first wife, Cable's mother, and a clone of Jean Grey created by Mr. Sinister. After Cyclops abandoned her and her son, she was tricked and seduced by demons to harness great demonic power.
Peter Parker's aunt-by-marriage and one of the most important people in his life.
Originally, Count Nefaria was just an ambitious Maggia Don who hired mad scientists and super-villains. Later, becoming super-powered himself. Luchino stands as one of the Avengers' most powerful enemies, though not one of their most recurring.
Silvio Manfredi has always been some kind of villain. His body is almost completly made up of cybernetic parts and he is almost like a human robot.
Digger is a gamma mutated monster made up of 13 dead gangsters.
Ravencroft Sanitarium for the Criminally Insane psychiatrist. She has been the Doctor to Carnage, Shriek, Carrion, Vermin, Chameleon, Massacre and Venom to name a few. Later she becomes the villain called Goblin Queen.
Mercenary for hire.
Otto Octavius' apprentice, who took the title of her mentor after Octavius' death, and has fought Spider-Man many times.
Romy Stephanie Watson is an artificial being created by Dr. Benjamin Rabin to "chain" down Mary Jane Watson.
A debt collector who was sent to limbo and turned into a demon bounty hunter by Madelyne Pryor.
Elaine Coll, AKA Scorpia is a psychotic woman with a similar suit to that of the Scorpion and an enemy of Spider-Man.
He is a mathematician who tried to merge with Wayep to become Kuhul Ajaw. He was purged from existence following his latest attempt to attain Godhood.
Owen Watson is an artificial being whom was created by Dr. Benjamin Rabin to "chain" down Mary Jane Watson.
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