they have to have some kind of superpower. so don't say stryker or humans.

Bastion

@thorson: Does Bastion count? Cause if so I am going with him.

Sinister.

People forget this guy's not a mutant.

If, for some reason he doesn't count, I'm going with the Juggernaut.

and if he doesn't count, I'll go with Nimrod.

@oldnightcrawler said:

Sinister.

People forget this guy's not a mutant.

If, for some reason he doesn't count, I'm going with the Juggernaut.

and if he doesn't count, I'll go with Nimrod.

Totally forgot Sinister. Lol which is terrible considering his importance to my favorite X-Character. For Shame...... T-T

John Sublime. The guy founded the U-Men, created Kick, supplied Cassandra Nova with the tech needed to annihilate Genosha (okay this is more implied than overt but still...), took part in the Weapon X program, and numerous other activities during Grant Morrison's run on New X-Men.

Vargas. Cause he's a Claremont creation, and the true Homo Superior.

Juggernaut.

Mr Sinister or Juggernaut

@joygirl: Agreed Juggs

Sinister

Mr. Sinister, no disrespect to Juggs but Sinister has hurt far more of the X-men on a far deeper level than all most all X-men villains combined. Apoc and Magneto are probably his only real peers in this department.

@shadowswordmaster said:

Bastion

closest guy to end the mutant race Bastion is number 1

@raggedscarecrow said:

John Sublime. The guy founded the U-Men, created Kick, supplied Cassandra Nova with the tech needed to annihilate Genosha (okay this is more implied than overt but still...), took part in the Weapon X program, and numerous other activities during Grant Morrison's run on New X-Men.

oh, good call! I totally forgot about this guy. I don't know if I'd consider him one of their greatest villains, but he definitely did enough damage to be a contender.

The Sentinels

If they don't count, then Mr. Sinister.

The Sentinels and Juggernaut.

Pandemic... he had such promise.

Bastion and the Sentinels are more an enemy to all mutants than X-men specific enemies

Scar

The Avengers

Shadow King?

I would've said Onslaught, but he was less X-Men and did originate from Xavier, so he was hard to gauge.

Medusa.

The bipolar, red carpet, tramp is a basket case.

sinster or sentinels

Bendis

Bastion, Juggernaut, and currently BB + Medusa

Black Bolt and Medusa.

If it wasn't for the kindness of the X-Men, they'll already die in Death of X.

Sinister.

Scarlet Witch

Nimrod/Bastion

Nimrod, bastion, Sentinels in general, Dracula, was a big xmen enemy. the reavers. Gladiator was a xmen villain for a min I believe too

Sinister. This guy needs a proper writer who isn't Lemire or Soule (both Wolverines and Extra appearances were pathetic) to bring back his glorious Uncanny makeover back.

Bastion. No one came closer to finishing the mutants.

mr. sinister isn't considered a mutant? Didn't apocalpyse alter his genetics or something thus making him a mutant?

Sinister

Dark Phoenix should also be up there, after all, it didn't inhabit Jean as Dark Phoenix until Endsong.

@raggedscarecrow: Sublime have actual reason to eradicate mutants too, they would be perfect mastermind behind m-day with wanda using 'kick' drug which let sublime to manipulated her mind.

Scarlet Witch.

the current writers and editors along with Marvel/Disney are the biggest enemies of the X-men.

Lol Disney their superpower you ask? Money

Mr. Sinister.

The entire marvel united states government. Terrible people

Written to his potential, Juggernaut is a walking nightmare.

Shadow King

Wanda