So as we all know, Miles Morales is the new Spider-Man in the Ultimate series, and Otto Octavius is currently prancing around in Peter's body. Most of us don't want to see SpOck on the big screen, and a lot of others don't want to see Miles either. But what if at the end of the last TASM movie Peter was to die and Miles was to have an appearance taking up the Spidey throne? This wouldn't necessarily have to lead into sequels with the character (think The Dark Knight Rises).
Personally, I'd like to see it.