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The Jackal is an enemy of Spider-Man who played a big role in both of the Clone Sagas. He has since seemingly returned to infest Manhattan with spider-powers for his own sinister ends, organizing test subjects into a spider-powered army.
Frank Oliver with his superhuman leaping abilities was the criminal better known as the Kangaroo. After Frank's death, another person named Brian Hibbs took over as the Kangaroo.
Mary Jane Watson is an actress and a major love interest of Peter Parker aka Spider-Man. They have had a long and dramatic on-and-off-again relationship. She's one of the few people who know who he is and still supports him as a close friend and confidante.
The Son of Black Tarantula and Black Tarantula himself in MC2 universe.
Jimmy transformed into Batwing after consuming chemically tainted water and came into conflict with Spider Man. Spider Man eventually befriended Jimmy and now he is currently a member of the Initiative.
Frog-Man is Eugene Patilio, the son of the former super-villain Leap-Frog, who hoped to do good and become a hero. He clumsily tried to battle crime to redeem his father's name. His only "power" is the ability to leap great distances with electrical coils in his boots.
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