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The clone of May Parker (Spider-Girl). She was biologically reengineered to be a symbiote hybrid. After naming herself April in order to interact with ordinary life, she gave herself the name Mayhem to operate under in her superhuman activities. April dies in a building explosion while fighting Spider-Girl.
Mattie Franklin was the third person to be a costumed super-heroine called Spider-Woman.
Member of a crime family in South America, she is a constant foe of both Normie Osborn and Spider-Girl. She is in the MC2 universe.
Rumor monger and scandal sheet printer, Dexter Bennett became the latest owner of the Daily Bugle after a hostile buyout of long-time owner J. Jonah Jameson.
Rigger Ruiz is an army member of Code Blue
The world's first "live streaming super-villain." She commits crimes to get more hits on her webpage.
The father of the former editor of The Daily Bugle, J. Jonah Jameson, and currently married to Peter Parker's Aunt May.
A journalist who worked at the Daily Bugle along with Peter Parker and after Civil War in Front Line newspaper. She seems to like sarcastic humor and Peter is usually the joke.
13 year old daughter of Kraven the Hunter. Now walking in her father's footsteps, she continues the hunt for Spider-Man.
Anya Sofía Corazón is a 17 year old super-heroine who originally went by the name Araña and had a symbiotic exoskeleton which emanated from her spider-shaped tattoo. She then lost those powers and instead gained new powers similar to that of Spider-Man. Anya currently goes by the name of Spider-Girl.
Michelle is the sister of Vin Gonzales and Peter Parker's former roommate.
A new Spiderman enemy who thinks Peter Parker is Ben Reiley. He claims Ben killed his family and he is looking for vengeance.
Sasha was married to Kraven the Hunter.
Spider-Man's cousin.
Don Silvio aka Silverback is an old crime boss.
A female criminal who adopted her codename in Stilt-Man's honor. Participated in Purple Man's Villains for Hire.
Kaine was the first clone of Spider-Man created by the Jackal. He was suffering from clone degeneration and became an assassin and spent years tormenting his clone brother, Ben Reilly. He has since taken up the mantle his now dead brother as the new Scarlet Spider.
Former cat burglar Felicia Hardy became a crime fighter when she became romantically attracted to and involved with Spider-Man. Felicia has the ability to instill "bad luck" around others - this comes in handy when fighting crime!
J. Jonah Jameson is the former employer of Peter B. Parker and remains an aggravate of Spider-Man. He was once the chief editor and publisher of the Daily Bugle, a New York newspaper, and the mayor of New York before his resignation amidst scandal resulting from Superior Spider Man and the Goblin Nation. He now is a host of a show on the F.A.C.T. News Channel
Peter Parker's aunt-by-marriage and one of the most important people in his life.
The daughter of Peter Parker, the original Spider-Man, May "Mayday" Parker continues her father's legacy as the Spider-Woman of Earth-982 (MC2 Universe).
A former investigative journalist for the Daily Bugle and current owner of the newspaper Front Line who uses his friendships with Daredevil and Spider-Man to get information on criminals.
The second and most successful clone of Spider-Man created by the Jackal. A superhero known as the Scarlet Spider, Reilly later replaced Peter Parker for a time as Spider-Man after he found out that all this time he was the original and not Peter. Ben met his ultimate demise in the fight against the Green Goblin which led to Peter becoming Spider-Man once again, after he found out that he is the real Spider-Man after all.
Eddie Brock bonded with the dark alien symbiote after it was discarded by Spider-Man, becoming the first Venom. Later, Brock became Anti-Venom, but the symbiote was lost during the events of Spider-Island. Brock has also been forcibly bonded to the Toxin Symbiote by the Crime-Master, but has reluctantly given it up to stop Carnage. Recently he has re-bonded with Venom.
Wade Wilson is a former test subject of the Weapon X program, where he received his regenerative healing factor through the scientific experiments conducted upon him. A prominent enemy, ally and later, member of X-Force. He's famous for breaking the Fourth Wall.
Peter Parker was bitten by a radioactive spider as a teenager, granting him spider-like powers. After the death of his Uncle Ben, Peter learned that "with great power, comes great responsibility." Swearing to always protect the innocent from harm, Peter Parker became Spider-Man.
Diablo is a 9th century alchemist with aspirations of world dominance. He is able to produce any number of amazing potions that defy scientific analysis. Diablo does not seem to age. He is an enemy of the Fantastic Four.
Madame web is a mutant with precognitive powers. She retains her powers after M-Day. Madame Web also is the one who reminds Peter Parker who he is when he starts to think about not being Spider-man. Was played by Stan Lee's wife Joan in the 90s cartoon.
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