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Through a mix of biochemistry and mutation the scientists of Project: USA created a race of enhanced humans, the Ultra Sapiens. Each Ultra Sapien has a biogenetic mark somewhere on their body that looks like a tattoo, but other than that most of them look like normal humans. These Ultras belonged to America and were kept secret and under control for years until some of the Ultra Sapiens got together and destroyed the project so all the superhumans could escape. The now-free and untraceable Ultras spread around the world to live their own lives. Some became mercenaries or superheroes while others just hid and tried to have normal lives. This lead to the creation of the Hunter-Killers, a large group of recruited Ultra Sapiens that hunts down and captures (or kills) other Ultra Sapiens.

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